What is 5-hydroxytryptophan (5-HTP)

neolexan - brain 5-hydroxytryptophan (5-HTP) is a substance formed in the human body from tryptophan, an essential amino acid supplied to the body with the dietary food intake. In the brain, 5-hydroxytryptophan is further transformed into serotonin, a substance acting as a messenger transmitting nerve signals between cells in the brain. Serotonin is also known as the „happiness hormone”.
A supplementary intake of 5-hydroxytryptophan in the form of tablets increases serotonin levels in the brain, improving conditions associated with low serotonin levels without causing the common side effects of medicinal drugs intended for the treatment of such conditions.

Neolexan can be found on the pharmaceutical market in three forms:

Neolexan 50 mg, Neolexan 100 mg Neolexan SR.

Each tablet Neolexan 50 mg contains 50 mg of 5-hydroxytryptophan and Neolexan100 mg contains 100 mg of 5-hydroxytryptophan.

Neolexan SR is a pill form of 5-hydroxytryptophan (5 - HTP) with extended release. Each tablet Neolexan SR contains 150 mg 5-HTP.


Neolexan 50 mg and 100 mg are intended for use in people suffering from conditions associated with low levels of serotonin, as well as for persons on a diet and / or  withdrawing from harmful habits such as smoking, alcohol abuse, etc.

The prolonged release of 5-HTP, make ​​Neolexan SR suitable for use in indications requiring constant levels of 5-HTP in the body. Such conditions include: depression, anxiety, addictions, fibromyalgia, patients antiparkinsonian therapy.


Please inform your doctor if:

Any of the following conditions apply to you:

  • Liver failure
  • Renal failure
  • Gastric or duodenal ulcer
  • Impaired blood clotting
  • Breastfeeding
  • Down’s syndrome

You use any of the following drugs:

  • СSelective Serotonin Reuptake Inhibitors (SSRI), such as citalopram (Seropram), escitalopram (Cipralex), fluvoxamine (Fevarin), fluoxetine (Prozac), paroxetine (Seroxat, Paroxat) or sertraline (Zoloft);
  • Monoaminooxidase inhibitors (MAOI), such as tranylcypromine (Nardil), phenelzine (Parnate), or isocarboxazid (Marplan)
  • Tricyclic antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil);
  • Anti-AIDS drugs


At the beginning of treatment, some patients may experience mild nausea, which is transient and best prevented by starting with a low dose of Neolexan, gradually increasing it as necessary.


  • Pregnant women
  • Children under 12


The initial dose of Neolexan is usually 1 tablet 3 times daily. The effect of the agent does not usually occur immediately and the dose should not be adjusted before two weeks have elapsed. The dose may then be increased to 2 tablets 3 times daily.

For insomnia, the recommended dose is 1 to 6 tablets in a single intake 30-45 minutes before bedtime. Some patients may experience mild nausea when they take Neolexan for the first time, so it is recommended to start with 1 tablet before bedtime and gradually increase the dose as necessary.

If Neolexan is taken during weight-loss dieting, it is recommended to take 1 tablet 20 minutes before meals.

Do not stop taking the drug before you have consulted your doctor even if you start to feel better.


Conditions caused by low serotonin levels include:


Depression Depression is a condition requiring specialised medical care and is different from the well-known feelings of being in a bad mood or feeling "down". Depression is characterised by a loss of interest in normal everyday activities, lack of vigour, inability to concentrate, a feeling of helplessness, hopelessness and sadness, uselessness and ineptitude, disturbed sleep, low libido, significant weight gain or weight loss, fatigue, headache, etc. Depression is not a fault of character and cannot be blamed on the patient. It can be treated. Depression is caused by a combination of three factors: genetic predisposition, environmental factors and an imbalance of certain chemical substances in the brain. The most important among the latter is serotonin, which is severely decreased in depression..


Insomnia After a good sleep a person normally feels refreshed and recovered. This does not always depend on the duration, but rather on the quality of sleep. Sleep disturbances have various causes, but the ultimate cause is again a disturbed balance of chemical substances in the brain. The most important substance determining the onset and the duration of sleep is melatonin. However, melatonin levels in the brain and the sensitivity of brain structures to melatonin depend on serotonin levels. Serotonin plays a critical role in the quality of sleep. High serotonin levels cause a prolonged phase of deep sleep, allowing the brain to recover and a person to feel refreshed and rested, at the expense of the less important preparative phases of sleep. While melatonin-based agents have certain benefits in elderly patients with low melatonin levels, in younger adults insomnia and sleep disturbances respond much better to an increase in serotonin levels and hence to 5-hydroxy-tryptophane.

Anxiety and restlessness

Anxiety and restlessness are also caused by low serotonin levels, so increasing serotonin levels leads to significant improvement or even to the full disappearance of these conditions.

Migraine and headache

Migraine and headache Chronic headaches and migraine in particular are thought to result from low serotonin levels, probably due to its increased degradation in the brain. The intake of 5-hydroxy-tryptophane increases serotonin production in the body, reducing sensitivity to pain. 5-hydroxy-tryptophane decreases the number, severity and intensity of chronic headache and migraine attacks by over 70%.



Obesity During dieting, blood tryptophane levels and brain serotonin levels significantly decrease. The low serotonin levels in obese patients cause a strong desire to consume excessive amounts of carbohydrates, usually sweets, and subsequent overeating. The intake of 5-hydroxy-tryptophane during and after dieting increases serotonin levels, resulting in earlier satiation, better adherence to the diet, less overeating and weight loss.

Fibromyalgia is a chronic condition characterised by fatigue, pain in the muscles, joints and tendons and multiple oversensitive areas all over the body, often accompanied by low serotonin levels.
The use of 5-hydroxy-tryptophane relieves and helps to eliminate the symptoms of fibromyalgia without causing any adverse effects.


neolexan - Addictions During withdrawal from addictions such as alcohol abuse, smoking, etc., maintaining adequate serotonin levels by means of supplementary 5-hydroxy-tryptophane helps to keep off the habit and to cope with the withdrawal symptoms while performing everyday activities.