Adirex®
What is good to know about diarrhea?
Acute intestinal infections are the second most common illness after upper respiratory tract infections. According to the World Health Organization (WHO), diarrhea is defined as having three or more loose or mushy stools per day, often accompanied by changes in color and odor. This condition can lead to significant fluid and electrolyte loss, disrupting the body’s acid-base balance.
Diarrhea can be classified based on duration:
• Acute: Lasting up to 14 days.
• Subacute or Persistent: Lasting between 2 and 4 weeks.
• Chronic: Lasting over 4 weeks.
Acute diarrhea is most commonly caused by infections from viruses, bacteria, or parasites. In industrialized countries, 70-80% of acute intestinal infections are viral in origin. For children under five, Rotavirus is the leading cause of acute diarrhea, whereas in adults, Norovirus is more common. Other viral causes include Adenovirus and Enterovirus. Bacterial causes include enteropathogenic Escherichia coli, Salmonella, Shigella, and Vibrio cholerae. Traveler’s diarrhea is another frequent cause, often resulting from the body’s stress and reduced resistance to local bacteria in new environments.
Mechanisms of occurrence
Diarrhea is often a defense mechanism that helps the body eliminate harmful agents from the intestines or other organs. In the gastrointestinal tract, fluids are constantly secreted and absorbed. A healthy body typically absorbs about 99% of the fluids consumed and secreted by glands such as the salivary glands and pancreas. In these cases, bowel movements are well-formed and regular. However, disruptions to the normal absorption and secretion processes can lead to diarrhea.
a) Osmotic Diarrhea: Undigested carbohydrates in the small intestine cause water retention, altering stool consistency.
b) Secretory Diarrhea: Impaired absorption of sodium and increased secretion of chloride cause the body to release water into the small intestine. This type of diarrhea is typically triggered by infections or certain medications.
c) Motility Diarrhea: Conditions such as hyperthyroidism or irritable bowel syndrome (IBS) can speed up intestinal movement, reducing the time for fluid absorption and leading to liquid stools.
d) Inflammatory Diarrhea: Inflammatory bowel diseases result in the loss of epithelial cells, disrupting the intestinal lining and allowing water, electrolytes, and proteins to leak into the intestines. This type of diarrhea can involve a combination of the mechanisms above.
Therapeutic agents
Diarrhea usually results from the complex interaction of the mechanisms described above. Therefore, effective treatment should target each of these mechanisms. However, antidiarrheal treatments can differ in how they manage bowel movements.
It’s important to remember that diarrhea is a natural protective response to clear out harmful substances.
Medications that stop bowel movements by suppressing peristalsis (the movement of the intestines) can trap these harmful agents and their toxins, potentially delaying recovery. Therefore, this approach is not recommended for infectious diarrhea caused by viruses, bacteria, or parasites.
Infectious diarrhea should be treated with natural antidiarrheal agents that work through multiple mechanisms. These agents should not block normal intestinal passage or interfere with the body’s natural cleansing process. Moreover, they should avoid side effects such as secondary constipation or bloating. Clinically proven ingredients with antidiarrheal effects can neutralize harmful microorganisms and their toxins, protect the intestinal lining, prevent fluid and electrolyte loss, and restore the balance of intestinal microflora.
According to the European Society of Paediatric Gastroenterology, Hepatology, and Nutrition, the probiotic yeast Saccharomyces boulardii, the probiotic strain Lactobacillus rhamnosus GG, and the trace element zinc have shown the most significant benefits in reducing diarrheal episodes. A newer class of substances, known as mucosal protectors, also plays a role in protecting the intestinal lining, with albumin tannate being one such example.
Adirex® is a combination of 5 clinically proven ingredients that has a beneficial effect on the health of the gastrointestinal tract.
Adirex® maintains the normal frequency of defecation and the physiological water-salt composition and consistency of intestinal contents. Maintains the natural balance of the intestinal microflora. Intended to be taken at the first signs of acute intestinal discomfort.
Ingredients
Saccharomycetes boulardii
A probiotic yeast that contributes to the breakdown of toxins and the maintenance of normal gut microbiota. An extremely hardy probiotic yeast that is not affected even by antibiotics.
It was first isolated in 1923 by the French scientist Henri
Boulard. In the intestine produces enzymes that break down the toxins of disease-causing microorganisms. It supports the normal barrier function of the intestinal mucosa and its normal permeability to water and salts by strengthening the intercellular junctions. Contributes to the maintenance of normal intestinal microbiota.
Lactobacillus rhamnosus GG
One of the best-studied probiotic strains, with clinically proven beneficial effects in maintaining normal bowel frequency. A probiotic strain that contributes to reducing the duration of diarrhea and is effective in diarrhea of viral origin. Supports normal barrier function of the intestinal mucosa by strengthening intercellular junctions. It attaches to the intestinal wall and increases the population of beneficial bacteria in the intestine. Beneficial effect on local immunity in the intestine.
Zinc
An important trace element with a pronounced antiviral and antibacterial effect on the digestive system. Zinc favourably influences ion transport in the intestine. Maintains the normal barrier function of the intestinal wall. Effectively reduces the duration of diarrheal symptom and is a major recommended treatment for diarrhea by the World Health Organization.
Albumin tannate
Albumin tannate creates a protective layer over the intestinal mucosa, helping to preserve its natural barrier function. It shields the intestinal lining from harmful viruses, bacteria, and toxins, and also helps maintain the balance of water and electrolytes in the intestines.
Mannan oligosaccharides
Prebiotics, such as mannan oligosaccharides, promote the growth of beneficial bacteria in the gut, supporting local immunity in the digestive tract. Their structure helps prevent harmful bacteria from adhering to the intestinal lining, facilitating their quick removal from the body and further contributing to the balance of gut microbiota.
