Sinquanon®
Understanding the Impact of Antibiotics on Gut Microflora?
The human body hosts trillions of microorganisms, collectively known as the microflora, microbiota, or microbiome.
It is estimated that the human microbiota consists of around 100 trillion bacterial cells, outnumbering the cells of the human body by 10 to 1.
These microorganisms colonize areas exposed to the external environment, such as the skin, respiratory, urogenital, and gastrointestinal tracts.
These microorganisms colonize areas exposed to the external environment, such as the skin, respiratory, urogenital, and gastrointestinal tracts.
The colon is the most densely colonized part of the gastrointestinal tract, housing around 1 trillion microorganisms per gram of fecal matter, represented by hundreds of species. These microorganisms can be broadly categorized as beneficial or harmful.
Key Roles of the Microbiome in the Human Body?
Beneficial bacteria perform important metabolic, protective and immunological functions for human health, which are:
- Enhancing digestion and nutrient absorption in parts of the digestive system where nutrients accumulate due to slow bowel passage and poor absorption.
- Producing essential vitamins.
- Inhibiting the growth of harmful (pathogenic) bacteria.
- Stimulating the immune system to support overall health.
Although the composition of the microbiota varies between individuals, it remains relatively stable throughout life for any given individual. However, certain factors can disrupt this balance, with the intake of antibiotics being the leading factor.
Effects of Antibiotic Treatment on Microflora
Antibiotics are vital for treating bacterial infections, but they also impact beneficial gut bacteria. This can lead to both short- and long-term cosequences for gut health.
Restoring the microbiota after antibiotic therapy can take several months or even years. In some cases, specific strains of bacteria may be permanently lost, disrupting body functions and potentially leading to various health issues inside and outside the gastrointestinal system.
Antibiotic-associated diarrhea is a common complication, affecting up to 30% of patients. Irritable bowel syndrome may also develop shortly after antibiotic use or months and even years later.
Emerging research highlights the link between disrupted gut microbiota and long-term conditions like asthma, autism, and allergies. A disrupted balance between beneficial and harmful bacteria may lead to chronic inflammation, contributing to metabolic disorders, diabetes, and cardiovascular diseases. Reduced production of vitamin K, which is exclusively synthesized by gut bacteria, may also explain some bone and cardiovascular health problems.
The Role of Probiotics in Supporting Gut Health During Antibiotic Use
Probiotics are increasingly used to help restore balance to the microbiome during and after antibiotic treatment. Probiotics are live microorganisms that provide health benefits when consumed in adequate amounts.
One of the most critical factors for microbiome recovery is the dosage of the probiotic. ESPGHAN (European Society of Paediatric Gastroenterology, Hepatology and Nutrition) notes that probiotics’ effectiveness is dose-dependent, with optimal results seen at doses between 10 and 100 billion CFU (colony-forming units).
The diversity and selection of strains in a probiotic formula are also key. Strains that are resistant to antibiotics and multiply rapidly help restore the microbiome to its natural balance faster.
Certain probiotic strains also produce metabolites that support the growth of surviving beneficial bacteria while inhibiting harmful ones, thus enhancing the recovery process after antibiotic use.
Sinquanon® Kids is a specialized probiotic, developed based on the latest scientific research and in line with the most current recommendations from leading global and European gastroenterology organizations.
It is specifically designed for individuals undergoing antibiotic treatment. Each daily dose contains an impressive 15 billion beneficial bacteria from 13 different probiotic strains, all carefully selected to restore and maintain healthy intestinal microflora during and after antibiotic use. While the high dose supports rapid recovery in the number of beneficial bacteria, the diverse strains ensure complete restoration of the microflora’s balance and functionality.
Ingredients
13 probiotic strains
Sinquanon® Kids is unique in containing 13 probiotic strains from three different genera: Lactobacilli, Bifidobacteria, and Saccharomyces. These strains are selected based on strict criteria, including their ability to resist stomach acids, survive common antibiotics, multiply rapidly, and work synergistically to enhance their overall effectiveness.
Lactobacilli
Lactobacilli are widely recognized for their numerous health benefits and are commonly used in probiotic products. Sinquanon® Kids includes seven strains of Lactobacilli, including the well-known Lactobacillus rhamnosus GG (LGG), one of the most thoroughly researched strains. It is highly recommended by leading organizations like the European Society of Paediatric Gastroenterology, Hepatology, and Nutrition, as well as the World Gastroenterology Organisation.
Lactobacilli are key members of the lactic acid bacteria group. They offer essential benefits, including rapid reproduction, high resistance to gastric acids, and the ability to adhere to the intestinal mucosa. They also produce metabolites that help maintain the balance of the intestinal microbial ecosystem and support the intestinal barrier.
Lactobacilli convert complex sugars into lactic acid, creating an acidic environment in the colon. This acidity promotes the growth of beneficial bacteria, helping them outcompete harmful ones. Lactobacilli also enhance nutrient absorption and support healthy intestinal peristalsis.
Bifidobacteria
Sinquanon® Kids includes five strains of Bifidobacteria, another beneficial genus commonly found in the colon.
These bacteria produce vital nutrients and metabolites that support both general body functions and a healthy gut ecosystem.
They are crucial for maintaining intestinal immunity by enhancing both local and systemic immune responses, as well as supporting the intestinal barrier. Bifidobacteria also play a significant role in synthesizing essential vitamins, such as vitamin K2 and various B vitamins.
Saccharomyces boulardii
Saccharomyces boulardii is a probiotic yeast included in Sinquanon® Kids. It is highly resistant to stomach acids, allowing it to reach the intestines alive. Unlike bacteria, Saccharomyces boulardii is naturally resistant to antibiotics, which ensures its survival and effectiveness during antibiotic treatment.
Numerous clinical studies have demonstrated its beneficial effects, including the production of enzymes that break down toxins in the intestines, helping to restore the balance of gut microflora, particularly after disruption caused by antibiotics.
In addition to maintaining a healthy gut flora, Saccharomyces boulardii supports intestinal physiology and strengthens both the gut barrier and immune function. This strain is highly recommended by leading organizations like the European Society of Paediatric Gastroenterology, Hepatology, and Nutrition and the World Gastroenterology Organization, making it a key component of Sinquanon® Kids formulation.
The diverse strains included inSinquanon® Kids work synergically to enhance each other’s beneficial effects.
A key feature of these strains is their rapid division rate, allowing them to double in mass approximately every 20 minutes. This rapid growth helps maintain the intestinal microflora at healthier levels, even during antibiotic treatment.
High Daily Dose
The effectiveness of probiotics during antibiotic treatment is dose-dependent, meaning higher doses lead to better results. Sinquanon® Kids provides an optimal daily dose of 15 billion beneficial bacteria – 10 to 1,000 times more than typical probiotics. This high dose allows Sinquanon® Kids to rapidly replenish a significant portion of the beneficial bacteria lost during antibiotic treatment and significantly reduce the risk of side effects like diarrhea, abdominal pain, and discomfort.
Three types of prebiotic
Prebiotics are fibers that serve as food for both the beneficial bacteria that normally inhabit our intestinal flora and the probiotics that we ingest. They provide much needed extra energy to help the good bacteria survive and start multiplying quickly. That’s why Sinquanon® Kids also includes a proprietary complex of three types of prebiotic specifically designed to stimulate the activity and faster division of the 13 probiotic strains included in its formula.
Together, these features make Sinquanon® Kids a specialized probiotic designed to rapidly restore both the quantity and diversity of gut microbiota lost during antibiotic treatment.
By doing so, it helps re-establish the natural balance of your intestinal microflora.
Directions on administration
How should my child take Sinquanon® Kids?
Sinquanon® Kids sachets are recommended for children from 0 to 5 years. Take 1 sachet daily for 5 to 14 days.
Dissolve the contents of the sachet in a little water or soft drink, stir and drink. It may also be mixed with food or breast milk.
To achieve a more lasting and safe effect, Sinquanon® Kids can be taken for at least another 2 weeks at the same dose.
Sinquanon® Kids should not be taken with hot drinks to avoid destroying the live bacteria in it.
Who should not take Sinquanon® Kids?
Do not give Sinquanon® Kids to your child if he or she have ever had an allergic reaction to any of its ingredients. If signs of an allergic reaction occur, discontinue use immediately.
Sinquanon® Kids are lactose and gluten free.
Do not exceed the recommended daily dose. This product should not be used as a substitute for a balanced diet.
What are the side effects of Sinquanon® Kids?
No side effects or contraindications have been reported for Sinquanon® Kids so far. It is well-tolerated, making it safe for extended use.
Store:
Store Sinquanon® Kids in its original packaging at a temperature below 25°C, in a dry place, away from direct sunlight and out of reach of children.
Do not use the product if the packaging is damaged or after the expiration date.
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