Sinquanon®
Understanding the Impact of Antibiotics on Gut Microbiota?
The human body hosts trillions of microorganisms, collectively known as the microflora, microbiota, or microbiome.
It is estimated that the human microflora consists of around 100 trillion bacterial cells, outnumbering the cells of the human body by 10 to 1.
These microorganisms colonize areas exposed to the external environment, such as the skin, respiratory, urogenital, and gastrointestinal tracts.
The colon is the most densely colonized part of the gastrointestinal tract, housing around 1 trillion microorganisms per gram of fecal matter, represented by hundreds of species. These microorganisms can be broadly categorized as beneficial or harmful.
Key Roles of the Microbiota in the Human Body?
Beneficial bacteria perform important metabolic, protective and immunological functions for human health, which are:
- Enhancing digestion and nutrients absorption in parts of the digestive system where nutrients accumulate due to slow bowel passage and poor absorption.
- Producing essential vitamins.
- Inhibiting the growth of harmful (pathogenic) bacteria.
- Stimulating the immune system to support overall health.
Although the composition of the microbiota varies between individuals, it remains relatively stable throughout life for any given individual. However, certain factors can disrupt this balance, with the intake of antibiotics being the leading factor.
Effects of Antibiotic Treatment on Microflora
Antibiotics are vital for treating bacterial infections, but they also impact beneficial gut bacteria. This can lead to both short- and long-term consequences for gut health.
Restoring the microbiota after antibiotic therapy can take several months or even years. In some cases, specific strains of bacteria may be permanently lost, disrupting body functions and potentially leading to various health issues inside and outside the gastrointestinal system.
Antibiotic-associated diarrhea is a common complication, affecting up to 30% of patients. Irritable bowel syndrome may also develop shortly after antibiotic use or months and even years later.
Emerging research highlights the link between disrupted gut microbiota and long-term conditions like asthma, autism, and allergies. A disrupted balance between beneficial and harmful bacteria may lead to chronic inflammation, contributing to metabolic disorders, diabetes, and cardiovascular diseases. Reduced production of vitamin K, which is exclusively synthesized by gut bacteria, may also explain some bone and cardiovascular health problems.
The Role of Probiotics in Supporting Gut Health During Antibiotic Use
Probiotics are increasingly used to help restore balance to the gut microbiota during and after antibiotic treatment. Probiotics are live microorganisms that provide health benefits when consumed in adequate amounts.
One of the most critical factors for microbiota recovery is the dosage of the probiotic. ESPGHAN (European Society of Paediatric Gastroenterology, Hepatology and Nutrition) notes that probiotics’ effectiveness is dose-dependent, with optimal results seen at doses between 10 and 100 billion CFU (colony-forming units).
The diversity and selection of strains in a probiotic formula are also key. Strains that are resistant to antibiotics and multiply rapidly help restore the microbiota to its natural balance faster.
Certain probiotic strains also produce metabolites that support the growth of surviving beneficial bacteria while inhibiting harmful ones, thus enhancing the recovery process after antibiotic use.
Sinquanon® is a specialized probiotic, developed in accordance with the latest scientific research and the most current recommendations of the leading world and European expert organizations in the field of gastroenterology.
It was specially created, with thought and care for people on antibiotic treatment. Proof of this is the huge amount of 100 billion good bacteria contained in one daily dose of Sinquanon®, as well as the diversity of 14 different probiotic strains, specially selected with a single goal – to restore and maintain normal intestinal microflora during and after antibiotic treatment. And while the high daily dose contributes to the rapid quantitative restoration of the intestinal microflora, the 14 strains support its full qualitative restoration.
Ingredients
14 Probiotic Strains
Sinquanon® is unique in containing 14 probiotic strains from four different genera: Lactobacilli, Bifidobacteria, Saccharomyces, and spore-forming Bacilli. These strains are selected based on strict criteria, including their ability to resist stomach acids, survive common antibiotics, multiply rapidly, and work synergistically to enhance their overall effectiveness.
Lactobacilli
Lactobacilli are widely recognized for their numerous health benefits and are commonly used in probiotic products. Sinquanon® includes seven strains of Lactobacilli, including the well-known Lactobacillus rhamnosus GG (LGG), one of the most thoroughly researched strains. It is highly recommended by leading organizations like the European Society of Paediatric Gastroenterology, Hepatology, and Nutrition, as well as the World Gastroenterology Organisation.
Lactobacilli are key members of the lactic acid bacteria group. They offer essential benefits, including rapid reproduction, high resistance to gastric acids, and the ability to adhere to the intestinal mucosa. They also produce metabolites that help maintain the balance of the intestinal microbial ecosystem and support the intestinal barrier.
Lactobacilli convert complex sugars into lactic acid, creating an acidic environment in the colon. This acidity promotes the growth of beneficial bacteria, helping them outcompete harmful ones. Lactobacilli also enhance nutrient absorption and support healthy intestinal peristalsis.
Bifidobacteria
Sinquanon® includes five strains of Bifidobacteria, another beneficial genus commonly found in the colon. These bacteria produce vital nutrients and metabolites that support both general body functions and a healthy gut ecosystem. They are crucial for maintaining intestinal immunity by enhancing both local and systemic immune responses, as well as supporting the intestinal barrier.
Bifidobacteria also play a significant role in synthesizing essential vitamins, such as vitamin K2 and various B vitamins.
Bacillus coagulans
Bacillus coagulans is a spore-forming probiotic known for its resilience. It easily survives the harsh, acidic environment of the stomach and withstands the effects of antibiotics by forming protective spores. Once in the intestines, Bacillus coagulans helps boost the population of beneficial bacteria.
Saccharomyces boullardii
Saccharomyces boulardii is a probiotic yeast included in Sinquanon®. It is highly resistant to stomach acids, allowing it to reach the intestines alive. Unlike bacteria, Saccharomyces boulardii is naturally resistant to antibiotics, which ensures its survival and effectiveness during antibiotic treatment.
Numerous clinical studies have demonstrated its beneficial effects, including the production of enzymes that break down toxins in the intestines, helping to restore the balance of gut microflora, particularly after disruption caused by antibiotics.
In addition to maintaining a healthy gut flora, Saccharomyces boulardii supports intestinal physiology and strengthens both the gut barrier and immune function. This strain is highly recommended by leading organizations like the European Society of Paediatric Gastroenterology, Hepatology, and Nutrition and the World Gastroenterology Organization, making it a key component of Sinquanon®‘s formulation.
The diverse strains included in Sinquanon® work synergically to enhance each other’s beneficial effects.
A key feature of these strains is their rapid division rate, allowing them to double in mass approximately every 20 minutes. This rapid growth helps maintain the intestinal microflora at healthier levels, even during antibiotic treatment.
High daily dose
The effectiveness of probiotics during antibiotic treatment is dose-dependent, meaning higher doses lead to better results. Sinquanon® provides an optimal daily dose of 100 billion beneficial bacteria – 10 to 1,000 times more than typical probiotics. This high dose allows Sinquanon® to rapidly replenish a significant portion of the beneficial bacteria lost during antibiotic treatment and significantly reduce the risk of side effects like diarrhea, abdominal pain, and discomfort.
Vitamin B complex
Did you know that your gut microflora plays a crucial role in producing essential B vitamins? When antibiotics disrupt the balance of your gut microflora, the body’s production of these vitamins is often reduced. To address this, Sinquanon® not only includes probiotics but also a complete complex of 6 B vitamins, provided at recommended daily doses to support your overall health during antibiotic treatment.
Three types of prebiotic
Prebiotics are fibers that act as food for the beneficial bacteria already present in the gut, as well as for the probiotics you consume. They supply essential energy, helping these good bacteria thrive and multiply more rapidly. To enhance this effect, Sinquanon® includes a proprietary blend of three types of prebiotics, specifically formulated to boost the activity and accelerate the growth of the 14 probiotic strains in its formula.
Special Protective Capsule
Sinquanon® uses a gastro-resistant capsule designed to survive the acidic environment of the stomach and dissolve only in the intestines. This ensures that the probiotic bacteria are delivered alive to the intestines, where they can effectively support gut health.
Together, these features make Sinquanon® a specialized probiotic designed to rapidly restore both the quantity and diversity of gut microbiota lost during antibiotic treatment. By doing so, it helps re-establish the natural balance of your intestinal microflora.
Directions on administration
How should I take Sinquanon®?
For adults and children over 5 years old, take 2 capsules once daily for 5 to 14 days.
For a more lasting and effective result, Sinquanon® can be taken for additional 2 weeks at a reduced dose of 1 capsule per day.
Avoid taking Sinquanon® with hot or alcoholic beverages, as these can destroy the live bacteria in the capsules.
Who should not take Sinquanon®?
Do not use Sinquanon® if you have had an allergic reaction to any of its ingredients. If signs of an allergic reaction occur, discontinue use immediately.
Sinquanon® is gluten- and lactose-free.
Do not exceed the recommended daily dose. This product should not be used as a substitute for a balanced diet.
What are the side effects of Sinquanon®?
There are no known side effects or contraindications associated with Sinquanon®. Its high tolerability allows for safe, extended use.
Sinquanon® is safe to use during pregnancy, breastfeeding, and by individuals with diabetes.
Note: Sinquanon® may cause bright yellow urine due to its riboflavin (Vitamin B2) content.
Storage instructions:
Store Sinquanon® in its original packaging at temperatures below 25°C, in a dry place, away from direct sunlight, and out of reach of children.
Do not use the product if the packaging is damaged or after the expiry date.
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