Novarix®
What should we know about varicose veins?
Varicose veins, also known as varices, represent the early stage of chronic venous disease (CVD) — a progressive condition that causes veins to enlarge, elongate, and curve. Though varicose veins can appear in different parts of the body, they most often affect the superficial veins in the legs.
The primary cause of CVD is the weakening of the vein walls, which leads to disrupted flow of venous blood back to the heart. When standing for long periods or living a sedentary lifestyle, blood flow in the veins slows down, causing venous stasis and increasing pressure in the veins. If the connective tissue is weak, the veins dilate, and the vein walls become damaged.
As the veins enlarge, the valves between them fail to close properly, leading to blood flowing backward (venous reflux). This causes blood retention in the legs, resulting in a feeling of heaviness, pain, swelling (edema), and changes in skin color. Venous reflux not only impairs normal blood circulation but also leads to trauma and inflammation of the vein walls. The veins’ elasticity is further compromised by the loss of collagen and elastin.
Fibrous tissue buildup can also alter the vein’s thickness.
Initial symptoms of CVD are often subtle and unrelated to vein health. People may attribute leg fatigue, pain, and heaviness to general malaise or physical fatigue. The problem becomes apparent only when veins protrude under the skin and can be easily seen and felt. Ignoring the issue can lead to reduced physical performance and a noticeable decline in quality of life.
Drug therapy plays an essential role in managing CVD at all stages. It can be used on its own or alongside surgical interventions (usually in more advanced stages of the disease).
The primary goal of pharmacological treatment is to reduce inflammation, enhance venous microcirculation, and improve lymphatic drainage. This, in turn, helps reduce swelling in the legs and alleviates discomfort. Treatment often includes the use of diosmin, hesperidin, horse chestnut extract, and non-steroidal anti-inflammatory drugs. Additionally, newer therapies focus not only on symptom relief but also on reinforcing the vein walls to slow disease progression.
Type III collagen and elastin, provided as bioactive peptides, help the body maintain strong and healthy blood vessel walls.
Novarix® is formulated to support vein health, elasticity, and tone. It supplies the body with essential substances that help maintain the integrity of vein walls. While Novarix® benefits veins and valves throughout the body, its most noticeable effects are in the superficial veins of the lower limbs.
Novarix® is an innovative complex formula of micronized purified flavonoid fraction (MPFF), collagen, and elastin.
Ingredients
Micronized Purified Flavonoid Fraction (MPFF)
The micronized purified flavonoid fraction contains 90% diosmin and 10% other flavonoids, primarily hesperidin. Both diosmin and hesperidin are widely recognized and very well-known compounds.
These flavonoids, commonly found in citrus fruit peels, are powerful antioxidants that protect cells from damage caused by free radicals and other environmental factors. They support vein health by maintaining blood vessel tone, promoting proper circulation in the legs, and regulating capillary permeability. Clinical studies confirm that these compounds improve venous wall health, which can enhance patients’ quality of life, providing a sensation of “lightness” in the legs. The flavonoids in Novarix® also contribute to the stability and strength of vein walls.
Diosmin, in its pure form, has low solubility in water, making it less easily absorbed by the body. To enhance its effectiveness, the flavonoids in Novarix® are purified and micronized to form a micronized purified flavonoid fraction (MPFF). Reducing the particle size, improves the absorption in the gastrointestinal tract and bioavailability. Numerous preclinical and clinical studies show that micronized diosmin is more potent than non-micronized diosmin.
Collagen
The human body contains more than 20 types of collagen, each serving a different function. Type III collagen plays a crucial role in the blood vessels, forming a delicate network that helps maintain the shape, structure, and volume of the vessels. The strength of this collagen network determines the overall strength of the vessel walls.
After the age of 30, natural collagen production begins to decline due to aging. Supplementing with additional collagen supports the body’s ability to maintain the health of blood vessel walls.
Elastin
Elastin is another key component of the vascular walls, responsible for maintaining their tone and elasticity. When elastin is correctly structured and is present in adequate amounts, the vessels can withstand added strain from activities such as prolonged standing, extended sitting, improper posture, etc.
