NOVARIX is intended for people with venous diseases, e.g. varicose veins, dilated capillaries, and hemorrhoids.

WHAT ARE venous disorders?

The most prevalent venous disorders in the world are varicose veins and hemorrhoids. In Bulgaria they affect more than 1.5 mln. people among the population aged 30 or over.

According to the most recent studies, the major cause for the development of varicose veins is vascular wall insufficiency, rather than an inflammatory process, as previously believed.

Venous walls are built mostly of type 3 collagen, elastin and smooth muscle cells. With the advance of age, synthesis of type 3 collagen in the body decreases and almost completely stops by the age of 30. As a result, the venous wall weakens and becomes vulnerable to deformation. This is consistent with the fact that the onset of varicose veins takes place after the age of 30-40 years.

Where the venous wall has been weakened and pressure in the veins increases, the wall succumbs to the increased load and that leads to dilatation and deformity of the veins, and to impaired blood circulation. This is what creates the prerequisites for varicose veins.

This happens most commonly during long hours of standing up, or maintaining an incorrect posture where the veins are pressed and blood flow along the veins to the heart becomes difficult. During the initial stages of the disease the vein is able to restore its shape when the intravenous pressure drops back to normal. With the progress of the disease, however, the vein becomes permanently dilated and deformed, and its valves become damaged.

Therefore, venous blood is unable to move properly and a portion of it moves backwards. Edema forms, the venous wall becomes inflamed and sustains further injury. A feeling of heavy feet develops, and later pain, redness, ankle swelling, calf edema, a hot sensation in the calves, pins and needles, cramps and a burning sensation occur as well.

The veins start to enlarge and become visible under the skin. The symptoms described above alert that prevention and therapy should be initiated. If the condition is neglected and left untreated, veins grow in size and start to bulge on the skin. The permanent edema caused by varicose veins leads to impaired skin nutrition and subsequently varicose ulcers are formed which are hard to heal. The outcomes of varicose veins may be quite serious, e.g. bleeding, venous thrombosis and phlebitis.

Dilated capillaries have no visible symptoms, but are the first manifestation of varicose veins. The onset of those is indicative that deeper veins have been affected, which cannot be noticed through the skin. Therefore, treatment of dilated capillaries should be combined with the treatment and prevention of the deeper lying veins. In this way, the onset of the disease and its accompanying complications can be prevented.

In cases of hemorrhoids the affected veins are those situated in the lower portion of the rectum (the colon) and in the anus. This condition is a little more common in males. Initially, symptoms are almost unnoticed, including itching and a burning sensation during bowel movement. With the progression of the disease its symptoms worsen and involve pain and bleeding during and after bowel movement. In case any of the above symptoms is present, it is necessary to take preventive measures to avoid progression of the disease.


Unlike other agents, NOVARIX targets the underlying cause of varicose vein disease, acting particularly on vascular wall insufficiency. In addition, NOVARIX has a venotonic effect (increases the venous tone), a vasoprotective effect (increases the resistance of small blood vessels), and suppresses the inflammatory process.

The composition of NOVARIX

Each tablet of NOVARIX contains:

  • 500 mg flavonoids:
    micronized purified flavonoid fraction, containing 90% (450 mg) diosmin, and 10% (50 mg) other flavonoids, e.g. hesperidin, diosmetin, linarine, etc.;
  • 100 mg hydrolysed type III collagen;
  • 50 mg elastin.

The biologically active substances in the composition of NOVARIX provide an excellent working formula for venous disorders:

  • Type III collagen

There are more than 20 types of collagen in the human body. Of those, type III collagen is of greatest importance for blood vessels. Its fibers build a fine network in the blood vessel wall which supports their shape, structure, and volume. The strength of the collagen network determines the strength of the vascular wall. Supplemental use of type III collagen allows the body to maintain healthy blood vessel walls. The type 3 collagen in the composition of NOVARIX has been hydrolyzed, to make its absorption in the body faster and reliable.

  • Elastin

The elastin in the composition of NOVARIX is another important building block of the vascular wall, which is responsible for conferring its tone and elasticity. Where elastin is of a proper structure, and in sufficient amounts, the vascular wall is capable of coping with additional loads resulting from a prolonged standing up position, prolonged sitting in unchanged position, incorrect pose, etc.

  • Flavonoids

Flavonoids act to suppress the inflammatory process in the venous wall. In addition, they increase venous tone and re-establish normal capillary permeability. As a result of those activities, edema and pain decrease, and are subsequently completely resolved. Furthermore, flavonoids in the composition of NOVARIX protect the capillaries and small blood vessels from multiple harmful factors (free radicals, inflammatory mediators), and increase their resistance and strength.

Flavonoids in NOVARIX have been purified and micronized. That makes them more rapidly and fully absorbable by the body, leading to faster relief of symptoms.


The prevention and treatment of venous disorders require an integral approach; therefore, NOVARIX tackles the cause underlying the disease through several mechanisms:

  • NOVARIX stimulates the synthesis of type III collagen and elastin, thus increasing the strength and elasticity of vascular walls.
  • NOVARIX suppresses the inflammatory process of the venous wall and of valves.
  • NOVARIX increases venous tone and re-establishes normal capillary permeability.
  • NOVARIX protects the capillaries and small blood vessels.

As a result NOVARIX:

  • Relieves edema and pain until completely resolved.
  • Decreases the risk of complications and recurrent disease..


Unless otherwise recommended by your doctor, take 1 NOVARIX tablet 2 times daily.

In cases of acute hemorrhoid attacks, in order to achieve faster effect, NOVARIX should be taken according to the following regimen:

2 tablets 3 times daily for 4 days, followed by
2 tablets 2 times daily for 3 days.
Afterwards the product should be taken according to the recommended daily dose – 1 tablet 2 times daily for a period of 30 to 90 days.

In some rare cases, stomach irritation may occur at the beginning of treatment. In such cases administration should be continued by taking NOVARIX during meals, or after meals.


Please, inform your doctor in case you are using any of the following:

- aspirin or anti-clotting agents;

- metronidazole containing products.


NOVARIX is not recommended in cases of hypersensitivity to any of the ingredients of the product.


Currently, there are no known side effects of this product, and no contraindications for its use. It has a very good tolerability, which provides for safe use during prolonged periods of time.