Neorenal SR

What is NEORENAL SR?

NEORENAL SR is a state of the art agent based on Neorenal, supplemented and enriched with biologically active substances and produced using new pharmaceutical technology. NEORENAL SR is intended for the treatment and prevention of kidney stones and inflammatory conditions of the urino-genital system with unmatched efficacy, convenient administration and no side effects.

COMPOSITION

NEORENAL SR contains a standardised birch leaf extract, a standardised Herniaria glabra extract and a patented combination of 3,5,7,3′,4′-penta-hydroxy-flavone and 3,7,3′,4′-tetra-hydroxy-flavone.
Each tablet of NEORENAL SR contains the following active substances: flavonoids 122 mg; tetracyclic triterpenes – 30 mg; tannins – 52 mg; triterpene saponins – 9 mg; phenolcarbonic acids – 4 mg; coumarins – 0.5 mg, betulorentic acid, potassium nitrate, etc.

INTENDED USE

NEORENAL SR improves the functioning of the kidneys and the excretory system. It facilitates the elimination of uric acid. It has a beneficial effect on the urino-genital system where there is a risk of kidney stone development or infection.

FURTHER INFORMATION

ACTIONS OF BIRCH EXTRACT AND HERNIARIA GLABRA EXTRACT
Birch leaf extract has diuretic, anti-inflammatory, antimicrobial, astringent and uricosuric action. The Herniaria glabra extract has antispasmodic action and additionally supplements and enhances the action of birch extract.

Diuretic action
The diuretic action is due to the flavonoids, the most important among them being hyperoside and myricitroside. The product also contains potassium nitrate, which enhances the diuretic effects of flavonoids. The mild and effective diuretic action results in the elimination of oedemas of various origins without causing irritation of the excretory system and of the kidneys.

Anti-inflammatory and antimicrobial effects
The antimicrobial activity is due both to the flavonoids and the terpenes and is particularly efficacious against bile tract and urino-genital infections. The product inhibits the growth of common pathogenic micro-organisms in these two systems of the body and relieves inflammation. Herniarin is a coumarine with antibiotic and antifungal properties which enhance the effects of flavonoids and terpenes.

Astringent effect
This action is mostly due to the tannins and is particularly beneficial during the acute phase of the inflammatory process, decreasing the amount of exudation.

Uricosuric effect
The product increases uric acid elimination, suppresses excessive production of uric acid and reduces the risk of kidney stone formation.

Antispasmodic effect
The antispasmodic effect is due to coumarines present in the composition of the Herniaria glabra extract, relaxing the smooth muscle along the course of the excretory system (ureters and urinary bladder).

INDICATIONS
Thanks to its actions , the combination of birch leaf and Herniaria glabra extracts has a beneficial effect in the following conditions:

Kidney stones
NEORENAL SR speeds up and facilitates the passing of kidney stones and particles from the kidneys and bladder, decreases the risk of oxalate, uric acid, phosphate and cystine kidney stone formation by increasing diuresis, restores urine pH to normal levels, relieves infections in the renal pelvis, suppresses the precipitation of calcium ions and speeds up their elimination with the urine. It reduces both the number of kidney stone attacks and the severity of their symptoms. It prolongs the intervals between attacks, relieves infection in the renal pelvis and restores the normal acidity of urine.

Following lithotripsy
NEORENAL SR is used to facilitate the elimination of residual particles from destroyed kidney stones in order to prevent the formation of new stones and prevent infection of the injured urinary tract tissues.

Inflammation of the urino-genital system (cystitis, urethritis, pyelonephritis)
NEORENAL SR eliminates pathogens causing urino-genital infections and relieves the symptoms of cystitis, urethritis and pyelonephritis by enhancing the elimination of urine and inhibiting pathogenic bacteria in the urino-genital system and thus speeds up the treatment process. It decreases the incidence of aggravated chronic urino-genital diseases (cystitis, urethritis and pyelonephritis) and enhances the effect of antibiotic treatment.

Gout
NEORENAL SR enhances the elimination and excretion of uric acid with the urine. The flavonoid Quercetin acts to suppress the enzyme activity of xanthine oxidase and xanthine dehydrogenase, which play a major role in the pathogenesis of gout.

Oedema
NEORENAL SR is beneficial in treating cardiovascular, renal, and inflammatory oedema, restoring the normal permeability of capillaries and improving conditions associated with fluid retention disorders.

Cellulitis
NEORENAL SR eliminates water retained in subcutaneous tissues, which is the major cause for the onset and development of cellulitis. Birch leaf extract stimulates blood circulation in the skin and restores the normal permeability of the capillaries. This results in improved elimination of waste metabolites from the skin and in the release of fluids retained in the skin and subcutaneous tissues. This gives rise to favourable conditions for the effective burning of fat in the subcutaneous fatty tissue.

DOSAGE

Indication Daily dose Minimum duration of treatment
Nephrolithiasis    
Kidney stone attacks 2 tablets
2 times daily
10 days
Prevention (in periods between kidney stone attacks) 1 tablet
2 times daily
60 days
Inflammatory conditions    
Acute cystitis, urethritis or pyelonephritis 2 tablets
2 times daily
10 days
Chronic pyelonephritis 1 tablet
2 times daily
90 days
Chronic cystitis or urethritis 1 tablet
2 times daily
60 days
Prevention of gout 1 tablet
2 times daily
90 days

The effect of Neorenal SR is enhanced by increasing fluid intake to about 1-2 litres daily.

The dosage of the product is based on body weight and on the severity of the condition. Unless otherwise prescribed by your doctor, take 1 to 2 tablets two times a day.

ADVERSE EFFECTS AND CONTRAINDICATIONS

There are no currently known adverse effects associated with this product and no known contraindications for its use.

KIDNEY STONES

Kidney stones are a very common condition affecting an estimated 2 to 3% of the population in Europe. About 0.12% of the population are affected by kidney stones every year (about 10,000 cases per year in Bulgaria). Bulgaria is considered an endemic region with a high incidence of kidney stones.

What are kidney stones?
Kidney stones are solid formations of dense crystalline matter mixed with urine proteins. The process of kidney stone formation and growth is painless and asymptomatic, but the attachment and growth of kidney stones causes kidney tissue damage. A kidney stone trying to be passed in urine will cause severe pain and bleeding and may obstruct the flow of urine from the kidney.
Pain is the most common symptom of kidney stones.

Causes of kidney stone formation
The composition and acidity (pH) of urine can change due to various factors, giving rise to conditions leading to stone formation. In most cases, kidney stone formation is due to the simultaneous occurrence of several factors of which the most important are:

ГGeographic and climatic factors
A hot and arid climate causes increased sweating. The urine becomes more concentrated and the levels of kidney stone-forming substances rise.

Nutrition
Diet is of major importance in the development of kidney stones. Reduced fluid intake is a major factor causing kidney stones, as it results in the production of smaller volumes of highly concentrated urine.

Impaired flow of urine
Obstructions in the flow of urine may be caused by adhesions, prostate adenoma, prolonged immobilisation in bed, etc. When urine is retained in particular places (e.g. in the kidneys or bladder), its concentration increases and precipitation occurs.

Increased levels of kidney stone-forming substances in urine
The most common cause is metabolic and endocrine disorders affecting the uptake and metabolism of substances in the body.

Urinary infection is a significant factor
Exfoliated cells, pus and blood clots act as nuclei for the formation of kidney stones.

Urine acidity (рН)
Is a very important factor for the solubility of salts. In an acidic environment (pH 5.4 – 5.8) uric acid is poorly soluble. This is a major condition leading to the formation of uric acid stones. Struvite stones are formed in an alkaline environment (pH 7.5-8.0) which occurs in infected urine.

TYPES OF KIDNEY STONES


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INFLAMMATION OF THE URINO-GENITAL SYSTEM

Photograph of a pregnant womanInflammations of the urinary tract, such as cystitis and urethritis, are among the most common diseases. According to various studies, every second female has had a urinary tract infection at some point in her life. Urinary tract infection is often recurrent and in some women becomes a chronic condition occurring several times per year. The anatomy of the female urino-genital tract is a factor causing increased incidence of urinary tract infections.

Urinary tract infections in pregnant women are a matter of particular concern. In such patients the uterus is enlarged and compresses the bladder and the urinary tract, creating conditions for the onset of infections. Untreated urinary tract infections during pregnancy are associated with an increased risk of pyelonephritis, premature labour, etc.

en_neorenal-l-formi_270_270The most common cause of chronic urinary infections are so-called L-forms of bacteria. L-forms are pathogenic micro-organisms which have changed to adapt themselves to environmental factors (usually antibiotics), becoming unsusceptible to the action of antibiotics. In this state they are unable to cause disease, but they do not respond to antibiotics or the immune system and may remain in the body. When conditions become favourable to the bacterial L-forms, they are activated and regain their pathogenic properties.

What is cystitis?en_diagrama_cistit_353
Cystitis is an inflammation of the mucosal lining of the bladder. The most common pathogen in cystitis is a bacterium called Escherichia coli.

 

The symptoms of cystitis include frequent urination accompanied with pain and a burning sensation. Initially, patients may report discomfort and cloudy urine with an unusual odour and colour, sometimes containing blood. Pyrexia, fever and general weakness may also be present.
Multiple factors play a role in the development of cystitis: exposure to a cold environment, urine retention in the bladder, pregnancy, urethral catheterisation, constipation, exhaustion, defloration, menopause, etc.
ДUrinary system disorders are an additional risk factor if they restrict the flow of urine. Such disorders include kidney stones, prostate enlargement in males and other disorders of the lower pelvis.

What is urethritis?Photograph of the bladder and the urethra
Urethritis is an inflammation of the urethral canal which may be caused by various bacterial, fungal or viral pathogens. Symptoms vary from itching and a burning sensation to severe pain during urination.

Photograph of the bladder and the urethra