NEORENAL is a state of the art agent with comprehensive effect in:

  • treatment and prevention of kidney stones
  • treatment and prevention of inflammatory conditions of the urino-genital system (cystitis, urethritis and pyelonephritis)
  • treatment and prevention of gout

NEORENAL facilitates the functioning of the kidneys and the urinary system. It enhances the elimination of uric acid from the body and improves the condition of the urino-genital system where there is a risk of kidney stones and infection.


NEORENAL is a herbal product containing a standardised birch leaf extract and a patented combination of 3,5,7,3′,4′-penta-hydroxy-flavone and 3,7,3′,4′-tetra-hydroxy-flavone. Each tablet of NEORENAL contains 390 mg standardised dry birch leaf extract comprising 330 mg of active ingredients including: flavonoids – 80 mg; tetracyclic triterpenes – 20 mg, tannins – 32 mg, betulorentic acid, potassium nitrate, etc.


Birch leaf extract has diuretic, choleretic, anti-inflammatory, antimicrobial, astringent and uricosuric effect.

Diuretic effect
Neorenal improves fluid excretion without disturbing the salt balance in the body. The diuretic effect is mild but effective and helps to eliminate oedemas of various origins without causing irritation of the excretory system and kidneys. The diuretic action is due to the flavonoids, the most important among them being hyperoside and myricitroside. The extract also contains potassium nitrate, which enhances the diuretic effects of flavonoids.

Anti-inflammatory and antimicrobial effects
Neorenal relieves inflammation in the urino-genital system, inhibiting the growth of pathogenic bacteria. The antimicrobial effect is due both to the flavonoids and the terpenes and is particularly pronounced in the urino-genital system.

Astringent effect
Neorenal causes the epithelial tissue along the urino-genital tract to contract. This is very important during the acute phase of the inflammatory process, decreasing the amount of exudation. This action is mostly due to the tannins.

Uricosuric effect
Neorenal increases uric acid elimination, suppresses excessive production of uric acid and reduces the risk of kidney stone formation.

Thanks to its actions , birch extract has a beneficial effect in the following conditions:

Kidney stones
Neorenal speeds up the passing of kidney stones and particles from the kidneys and bladder, decreases the risk of oxalate, uric acid, phosphate and cystine kidney stones formation by increasing diuresis, restores urine pH to normal levels, relieves infections in the renal pelvis, suppresses the precipitation of calcium ions and speeds up their elimination with the urine. As a result, both the number of kidney stone attacks and the severity of their symptoms decrease. Neorenal prolongs the intervals between attacks, relieves infection in the renal pelvis and restores the normal acidity of urine.

Following lithotripsy
Neorenal is used to facilitate the elimination of residual particles from destroyed kidney stones in order to prevent the formation of new stones and infection of the injured urinary tract tissues.

3. Inflammation of the urino-genital system (cystitis, urethritis, pyelonephritis):
Neorenal eliminates pathogens causing urino-genital infections and relieves the symptoms of cystitis, urethritis and pyelonephritis by enhancing the elimination of urine and inhibiting pathogenic bacteria in the urino-genital system. It decreases the incidence of aggravated chronic urino-genital diseases (cystitis, urethritis, pyelonephritis) and enhances the effect of antibiotic treatment.

In chronic conditions, Neorenal may be used for extended periods (more than 6 months) due to its excellent tolerability and safety profile.

Neorenal enhances the elimination of uric acid with the urine and decreases uric acid levels in the blood. The flavonoid Quercetin acts to suppress the enzyme activity of xanthine oxidase and xanthine dehydrogenase, which play a major role in the pathogenesis of gout.

Neorenal is beneficial in cases of cardiovascular, renal and inflammatory oedema, restoring the normal permeability of capillaries and relieving fluid retention disorders.

Neorenal eliminates water retained in subcutaneous tissues, which is the major cause for the onset and development of cellulitis. Birch leaf extract stimulates blood circulation in the skin and restores the normal permeability of the capillaries. This results in improved elimination of waste metabolites from the skin and in the release of fluids retained in the skin and subcutaneous tissues. This gives rise to favourable conditions for the effective burning of fat in the subcutaneous fatty tissue.


Indication Daily dose Minimum duration of treatment
Kidney stone attacks 2 tablets
3 times daily
10 days
Prevention (in periods between kidney stone attacks) 1 tablet
3 times daily
60 days
Inflammatory conditions    
Acute cystitis, urethritis or pyelonephritis 2 tablets
3 times daily
10 days
Chronic pyelonephritis 1 tablet
3 times daily
90 days
Chronic cystitis or urethritis 1 tablet
3 times daily
60 days
Prevention of gout 1 tablet
3 times daily
90 days

The effect of Neorenal SR is enhanced by increasing fluid intake to about 1-2 litres daily.
The dosage of the product is based on body weight and on the severity of the condition. Unless otherwise prescribed by your doctor, take 1 to 2 tablets two times a day.


There are no currently known adverse effects associated with this product and no known contraindications for its use.


Kidney stones are a very common condition affecting an estimated 2 to 3% of the population in Europe. About 0.12% of the population are affected by kidney stones every year (about 10,000 cases per year in Bulgaria). Bulgaria is considered an endemic region with a high incidence of kidney stones.

What are kidney stones?
Kidney stones are solid formations of dense crystalline matter mixed with urine proteins. The process of kidney stone formation and growth is painless and asymptomatic, but the attachment and growth of kidney stones causes kidney tissue damage. A kidney stone trying to be passed in urine will cause severe pain and bleeding and may obstruct the flow of urine from the kidney.
Pain is the most common symptom of kidney stones.

Causes of kidney stone formation
The composition and acidity (pH) of urine can change due to various factors, giving rise to conditions leading to stone formation. In most cases, kidney stone formation is due to the simultaneous occurrence of several factors of which the most important are:

ГGeographic and climatic factors
A hot and arid climate causes increased sweating. The urine becomes more concentrated and the levels of kidney stone-forming substances rise.

Diet is of major importance in the development of kidney stones. Reduced fluid intake is a major factor causing kidney stones, as it results in the production of smaller volumes of highly concentrated urine.

Impaired flow of urine
Obstructions in the flow of urine may be caused by adhesions, prostate adenoma, prolonged immobilisation in bed, etc. When urine is retained in particular places (e.g. in the kidneys or bladder), its concentration increases and precipitation occurs.

Increased levels of kidney stone-forming substances in urine
The most common cause is metabolic and endocrine disorders affecting the uptake and metabolism of substances in the body.

Urinary infection is a significant factor
Exfoliated cells, pus and blood clots act as nuclei for the formation of kidney stones.

Urine acidity (рН)
Is a very important factor for the solubility of salts. In an acidic environment (pH 5.4 – 5.8) uric acid is poorly soluble. This is a major condition leading to the formation of uric acid stones. Struvite stones are formed in an alkaline environment (pH 7.5-8.0) which occurs in infected urine.




Urinary tract infections in pregnant womenInflammations of the urinary tract, such as cystitis and urethritis, are among the most common diseases. According to various studies, every second female has had a urinary tract infection at some point in her life. Urinary tract infection is often recurrent and in some women becomes a chronic condition occurring several times per year. The anatomy of the female urino-genital tract is a factor causing increased incidence of urinary tract infections.

Urinary tract infections in pregnant women are a matter of particular concern. In such patients the uterus is enlarged and compresses the bladder and the urinary tract, creating conditions for the onset of infections. Untreated urinary tract infections during pregnancy are associated with an increased risk of pyelonephritis, premature labour, etc.

L-forms The most common cause of chronic urinary infections are so-called L-forms of bacteria. L-forms are pathogenic micro-organisms which have changed to adapt themselves to environmental factors (usually antibiotics), becoming unsusceptible to the action of antibiotics. In this state they are unable to cause disease, but they do not respond to antibiotics or the immune system and may remain in the body. When conditions become favourable to the bacterial L-forms, they are activated and regain their pathogenic properties.

What is cystitis?What is cystitis
Cystitis is an inflammation of the mucosal lining of the bladder. The most common pathogen in cystitis is a bacterium called Escherichia coli.

The symptoms of cystitis include frequent urination accompanied with pain and a burning sensation. Initially, patients may report discomfort and cloudy urine with an unusual odour and colour, sometimes containing blood. Pyrexia, fever and general weakness may also be present.
Multiple factors play a role in the development of cystitis: exposure to a cold environment, urine retention in the bladder, pregnancy, urethral catheterisation, constipation, exhaustion, defloration, menopause, etc.
ДUrinary system disorders are an additional risk factor if they restrict the flow of urine. Such disorders include kidney stones, prostate enlargement in males and other disorders of the lower pelvis.

What is urethritis?bladder and the urethra
Urethritis is an inflammation of the urethral canal which may be caused by various bacterial, fungal or viral pathogens. Symptoms vary from itching and a burning sensation to severe pain during urination.

Photograph of the bladder and the urethra