Neopholic meta


NEOPHOLIC МЕТА is supplied in blister packs of 30 orange coloured tablets, each containing 0.4 mg of methylated folic acid – L-methylfolate.

L-methylfolate is the active form of folic acid. Folic acid in the body can only take effect after being transformed to L-methylfolate. Until then it is inactive and has no biological action. Insufficient folic acid in the body of the mother and of the foetus leads to congenital defects of the foetal spine and brain (spina bifida).

Comparison of the metabolism of NEOPHOLIC МЕТА and of folic acid.


The transformation of folic acid into L-methylfolate is a complex multi-stage process, but it fails to occur in 12% of pregnant women due to a genetic enzyme defect. In these cases there is a risk of spina bifida in the child even if the woman is taking folic acid. This risk can be eliminated by administering NEOPHOLIC META instead.


Do not start taking NEOPHOLIC META if:

  • You have ever experienced an allergic reaction to L-methylfolate or to any of the other ingredients of the tablet. The most common symptoms of allergy include rash, itching, swelling of the face and lips and shortness of breath. Consult your doctor if you develop any of these symptoms.

Please consult your doctor if:

  • You were born with spina bifida
  • You have had a previous abnormal pregnancy and as a result your child was born with spina bifida or with another neural tube defect.
  • You suffer from epilepsy and are on phenobarbital, phenytoin or pyrimidone treatment.
  • You take medicines which inhibit folic acid metabolism, i.e. methotrexate, trimethoprim, or medicines which decrease folic acid absorption from the gastrointestinal tract: contraceptives and anticonvulsants.
  • You have undergone surgical resection of your small intestine.

Those conditions require the use of larger doses of L-methylfolate.


A dose of 0.4 milligrammes has been approved in practices all over the world as a sufficient daily dose to compensate for the increased demand in pregnant women for the active form of folic acid, L-methylfolate. Unless otherwise prescribed by your doctor, take 1 tablet of NEOPHOLIC META daily. Do not forget to take your daily dose. In order to avoid missing a daily dose, make the intake of NEOPHOLIC META a part of your daily routine. The daily dose of NEOPHOLIC META should not exceed 2 tablets.


With regard to the normal course of pregnancy and decreasing the risk of spina bifida in the newborn baby it is recommended that you start taking NEOPHOLIC META at least 1 month before you become pregnant and continue treatment during the first three months of gestation. If your pregnancy has not been planned in advance, you should start taking NEOPHOLIC META as soon as you find out that you are pregnant. NEOPHOLIC META is absorbed in the body more rapidly than folic acid and almost immediately reaches levels sufficient for performing its biological functions and for decreasing the risk of spina bifida. It is therefore recommended that you start taking NEOPHOLIC META when a desired pregnancy is diagnosed if you have not previously taken folic acid.


L-methyl folate, like folic acid itself, is a very unstable chemical compound and when exposed to the environment it rapidly loses its biochemical activity and efficacy. If the tablets are kept in a vial or in bulk, the molecules of L-methylfolate will decompose to inactive products when exposed to environmental factors such as heat, light, air, ultraviolet radiation, etc. This means that the shelf life of the tablets cannot exceed two months. When the tablets are sold in blister packs, each tablet is reliably protected from environmental influences. The shelf life of folic acid in blister packs is extended to 2 years. For added security, NEOPHOLIC META tablets are sold in blister packs in opaque white foil which provides additional protection from the destructive action of sunlight.


spina bifidaSpina bifida is a serious congenital defect of the spinal column. It affects the spinal cord, the vertebrae, the muscles and the skin which form the spine. The defect appears during the formation of the brain and of the spinal cord during the fourth week of gestation, i.e. six weeks after the last regular menstruation. In most cases it occurs before the woman becomes aware of her pregnancy.

Depending on the severity of spina bifida, the defect may be visible on the newborn baby’s back, but in milder cases no obvious anatomical lesions are present. In the most severe forms the whole spine remains unclosed and the child cannot survive. In milder forms, permanent weakness of the legs, decreased sensitivity and walking difficulties may be present. These forms frequently lead to disabilities. The mildest forms involve urinary incontinence and difficulty in controlling defecation.

Spina bifida can affect the baby of any mother even in cases where there is no family history of such a defect in either of the parents. On average 1 baby in 1000 is affected by spina bifida and another 1 in 1000 is born with some other neural tube defect. The neural tube is a foetal structure from which the spine and the brain develop.

Taking 0.4 milligrammes of folic acid for one month before conception and during the first three months of gestation reduces the risk of spina bifida by up to 80%.

NEOPHOLIC GUARANTEES Българско дружество по акушерство и гинекология

  • reliable prevention of spina bifida
  • effective action of the substance throughout its shelf-life
  • precise dosage recommended on the basis of international experience
  • quality complies with European Pharmacopoea requirements