Neolipidra Forte

WHAT IS NEOLIPIDRA FORTE

Each NEOLIPIDRA FORTE tablet contains 240 milligrammes of highly concentrated 1% extract of the metabolites of the Monascus purpureus yeast. Neolipidra Forte is a specially developed agent for reducing cholesterol and triglyceride levels. Neolipidra Forte is a biotechnology product obtained during the fermentation of Monascus purpureus yeasts. The biologically active substances in the composition of Neolipidra Forte are: 14 monacolins- inhibitors of HMG-CoA reductase, sterols, isoflavones, mono- and polyunsaturated fatty acids, saturated fatty acids and pigments.

HOW DOES NEOLIPIDRA FORTE ACT

кръвоносен съд - разрез
1. Normal blood vessel wall
2. Atherosclerotic plaq
3. Thrombotic blood vessel obturation

The major biologically active substances in NEOLIPIDRA FORTE are 14 monacolins which suppress the activity of HMG-CoA reductase, an enzyme responsible for the production of cholesterol in the liver. This results in decreased production of cholesterol in the liver and lower blood cholesterol levels. The decrease in cholesterol is partially due to the action of the other biologically active ingredients.

Neolipidra Forte is highly suitable for use in patients who cannot use other cholesterol reducing agents due to intolerance or adverse effects, incompatibility with agents administered for the accompanying disease or due to liver or kidney disorders

WHO SHOULD USE NEOLIPIDRA FORTE?

NEOLIPIDRA FORTE is recommended for use in all patients with increased cholesterol levels, regardless of the presence or absence of accompanying diseases, in order to decrease the risk of atherosclerosis, ischaemic heart disease, heart attacks and strokes.

WHO SHOULD NOT TAKE NEOLIPIDRA FORTE

Neolipidra Forte is not recommended for use in people with known hypersensitivity to any of the ingredients of the product. As cholesterol is a major cell building component, Neolipidra Forte is not recommended during pregnancy, for women planning to become pregnant and during breastfeeding. Decreased cholesterol in the mother’s body may adversely affect foetal development.

WHAT SHOULD I TELL MY DOCTOR BEFORE STARTING TO TAKE NEOLIPIDRA FORTE

Tell your doctor if:

  • You are using any of the following medicines:
    Cyclosporin
    Nephasodon

    Antifungal agents
    itraconazol, ketoconazol

    Fibrates
    gemfibrosil, bezafibrate, phenofibrate

    Antibiotics
    erythromycin, clarythromycin
    Coumarin anticoagulants
    HIV protease inhibitors

    Anti-arrhythmic drugs
    amyodaron, verapamil, propranolol
    Digoxin

    Hypoglycaemic drugs
    glypizide, chlorpropamide.
    Excessive grapefruit juice intake (> 1.14 litres daily)
  • You suffer from a serious infection
  • You have had an organ transplant
  • You have recently undergone surgery
  • You use alcohol in large quantities

 

WHAT ARE THE POSSIBLE ADVERSE EFFECTS OF NEOLIPIDRA FORTE?

In therapeutic doses, Neolipidra Forte does not cause any adverse effects either in short-term or long-term treatment. In cases of overdose, transient symptoms from the gastro-intestinal tract may be observed, such as heartburn (oesophageal reflux), a dry mouth, swelling of the stomach, flatulence and vomiting. When the dose is adjusted to normal, these symptoms will rapidly disappear. NEOLIPIDRA FORTE is generally well tolerated, and the adverse reactions are usually mild and transient

HOW TO TAKE NEOLIPIDRA FORTE

The dosage of NEOLIPIDRA FORTE is based on body weight and the severity of the condition. The recommended standard dose of Neolipidra Forte is 1 tablet of 240 mg 2 times a day, or a daily dose of 480 mg. The effect of Neolipidra Forte treatment should be evaluated at least 8 weeks after the start of treatment. If the results are unsatisfactory, the daily dose should be increased by 1 tablet, added to the evening dose, i.e. 1 tablet in the morning and 2 tablets in the evening or a total daily dose of 3 tablets (720 mg). If a further increase in the daily dose is necessary, you should take 2 tablets in the morning and 2 tablets in the evening, or a total daily dose of 4 tablets (960 mg/day). The daily dose of Neolipidra should not exceed 4 tablets or 960 mg.

WHAT MAKES NEOLIPIDRA FORTE DIFFERENT FROM OTHER CHOLESTEROL REDUCING DRUGS?

  • NEOLIPIDRA FORTE simultaneously reduces total cholesterol levels, LDL, or 'bad’ cholesterol levels and triglyceride levels
  • NEOLIPIDRA FORTE increases HDL, or ‘good’ cholesterol levels
  • NEOLIPIDRA FORTE does not interact with other medicines
  • NEOLIPIDRA FORTE may be used in all patients who cannot use other types of cholesterol reducing agents
  • NEOLIPIDRA FORTE can be used for long-term treatment over many years without causing liver damage
  • The use of NEOLIPIDRA FORTE does not even cause adverse effects in cases of treatment exceeding 4 years

WHAT YOU SHOULD KNOW ABOUT CHOLESTEROL

LDL (лош) и HDL (добър) холестерол Cholesterol is a type of lipid found in the blood. Blood cholesterol originates from two sources. Most cholesterol is produced in the liver, while the other source is the dietary food intake. The cholesterol in the body consists of LDL (‘bad’) cholesterol and of HDL (‘good’) cholesterol.

The total fasting cholesterol level should not exceed 5.17 mmol/L.

LDL-cholesterol is called ‘bad’cholesterol because it can be deposited on the inner surface of blood vessels, forming atherosclerotic plaques which are the major cause of atherosclerosis. In the course of time the plaques grow in size, obliterating the blood vessels, especially arteries. This restricts or blocks the blood supply to vital organs such as the brain and the heart, etc. High LDL-cholesterol is the major cause of cardiovascular disease, heart attacks and strokes. LDL levels in the body should not exceed 3.88 mmol/L.

HDL-cholesterol is called ‘good’ cholesterol because it prevents the deposition of ‘bad’ cholesterol on blood vessel walls and decreases the risk of atherosclerosis. Normal levels of ‘good’ cholesterol should be greater than 1.10 mmol/L.

Triglycerides are another type of lipids which enter the blood stream after food is digested in the stomach and in the intestines. High blood triglyceride levels increase the risk of cardiovascular disease. Normal triglyceride values should be lower than 2.28 mmol/L.

High levels of cholesterol in the blood (hypercholesterolaemia) are one of the major risk factors for the onset of numerous cardiovascular diseases such as atherosclerosis, heart attacks, strokes, etc.

High cholesterol levels themselves do not cause any symptoms. Many people are not even aware that they have high cholesterol levels and it is therefore important to check blood cholesterol levels regularly.

What are the possible causes of high cholesterol levels?

  • Food
    The most common cause of high cholesterol levels in about 70% of the population is the intake of foods high in fats. After meals, cholesterol from food passes into the circulatory system and is added to the cholesterol produced in the liver, giving and the total blood cholesterol value.
  • Hereditary predisposition
    High cholesterol levels may be due to familial predisposition as is the case in about 3% of the population. In these cases cholesterol levels are usually high fromform an early age and are not affected by diet.
  • Other illnesses
    Obesity, diabetes mellitus, hypothyroidism (underactive thyroid gland) Cushing’s syndrome (increased adrenal function) and other conditions account for high cholesterol levels in about 20% of the population.
  • Medicines
    Using certain medicines can cause an increase in blood cholesterol levels. These include oestrogens (female sex hormones), corticosteroids (anti-inflammatory agents), oral contraceptives, diuretics (medicines used to treat fluid retention) and beta-blockers (medicines used in the treatment of cardiovascular conditions).