ADIREX BABY

WHAT DO WE NEED TO KNOW ABOUT DIARRHOEA?

NATURE AND CAUSES OF THE CONDITION

Acute intestinal infections are the second most common infections after upper respiratory tract infections.

According to the World Health Organization’s latest definition, the diarrhoea syndrome includes three or more bowel movements with passing liquid or soft stools of changed colour and odour per day. This results in fluid and electrolyte loss and causes disturbance in the acid-base balance.

Diarrhoea may be determined as acute, if the condition is of limited duration of up to 14 days; sub-acute or persistent if it last between 2 and 4 weeks; and chronic - if it continues for more than 4 weeks.

The most common causes of acute diarrhoea are infectious agents, such as viruses, bacteria, and parasites.

In industrialized countries, 70-80% of acute intestinal infection cases have been caused by viruses. Unlike with children under 5 years of age, with whom the main causative agent of acute diarrhoea is Rotavirus, with adults the pathogen is Norovirus. Other common causative pathogens of acute diarrhoea are Adenovirus and Enterovirus.

Some of the important bacterial pathogens are the enteropathogenic Escherichia coli, Salmonella, Shigella, Vibrio cholerae.

Yet another common cause for the onset of acute diarrhoea is travel (traveller’s diarrhoea) because of the stress the body goes through and its lack of resistance to bacteria found in a new location.

 

THE MECHANISM OF DISEASE ONSET

Often, diarrhoea is a defence mechanism, protecting the body from different deleterious factors which act on the intestines or on other organs. The gastrointestinal tract is the site where exchange of liquids by secretion and absorption takes place every day. A healthy body absorbs (intakes) the larger portion (99%) of fluids both ingested through the mouth and secreted from various glands (e.g. the salivary glands, the pancreas). If this is the case, stools are well shaped and regular.

Diarrhoea may occur due to diverse causes which impair the mechanisms of intestinal absorption and secretion:

a) Undigested carbohydrates lead to fluid retention in the gut, thus changing the normal texture of stools. The above mechanism is known as osmotic diarrhoea.

b) Impaired absorption of sodium and increased secretion of chloride, when the body discharges water in the small intestine, which leads to the so called secretory diarrhoea. Secretory diarrhoea is most commonly associated with infection or the ingestion of certain medicinal products.

c) Certain types of illnesses, such as hyperthyroidism, irritable bowel syndrome, etc., may lead to faster intestinal passage, thus reducing the absorption time for fluids and causing the formation of liquid stools. This type of diarrhoea is known as motility diarrhoea.

d) Diarrhoea associated with intestinal inflammatory conditions is a result of the loss of epithelial cells which cover the mucosal lining and of the disruption of intercellular junctions, allowing water, electrolytes and proteins to accumulate in the intestinal cavity. This type of diarrhoea occurs as a combination of the abovementioned mechanisms.

 

THERAPEUTIC AGENTS

Diarrhoea is most commonly the result of the complex interaction of the abovementioned mechanisms of onset. The effective therapeutic management should be targeted at neutralizing each one of these mechanisms.

Apart from the complexity of their mode of action, antidiarrheal agents also differ considerably in the way in which they cope with the passing of diarrheal stools.

Diarrhoea is a normal defence reaction of self-cleansing. If diarrhoea is artificially stopped by means of medications which suppress intestinal peristalsis, the pathogenic organisms and their toxins will be retained. As this interferes with the healing and recovery processes, such therapies are not recommended for diarrhoea caused by viruses, bacteria or parasites. Infectious diarrhoea is best managed in a natural way, using antidiarrheal agents with a comprehensive mechanism of action which do not block the normal intestinal passage and its physiological cleansing and are not associated with adverse side effects such as secondary constipation and abdominal bloating.

This may be done by using ingredients with clinically established antidiarrheal effects which:

  • neutralize the pathogenic organisms and their toxins;
  • provide intestinal wall protection;
  • stop water and electrolyte loss;
  • restore the balance of gastrointestinal microflora.

According to the recommendations of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition, the referenced antidiarrheal agents of best established benefit in reducing diarrheal episodes are the probiotic yeasts Saccharomyces boulardii, the probiotic strain Lactobacillus rhamnosus GG and the micronutrient zinc. 

 

WHAT IS ADIREX BABY?

ADIREX BABY is a combination of 4 specially selected ingredients with clinical evidence of their favourable effect on gastrointestinal health. It maintains the normal frequency of bowel movements, the physiological water and electrolyte levels and the texture of intestinal contents. It supports the natural balance of intestinal flora.

Each sachet of ADIREX BABY contains:

Saccharomyces boulardii – 5 billion CFU*

Lactobacillus rhamnosus GG – 5 billion CFU*

Mannan-oligosaccharides – 200 mg

Zinc - 3,5 mg

*CFU - Colony forming units (viable cell count)

ADIREX BABY is a dietary supplement with sweetener.

 

HOW DOES ADIREX BABY WORK AND FOR WHOM IS IT INTENDED?

ADIREX BABY is appropriate for maintaining normal frequency of bowel movement and texture of intestinal contents.

Saccharomyces boulardii is a probiotic yeast. Being a remarkably viable microorganism, it is not affected even by antibiotics, survives while passing through the acidic environment of the stomach and after reaching the guts, it produces enzymes which break down toxins and contribute to maintaining normal gut flora.

It supports the physiological barrier function of intestinal epithelia and its normal water and salt permeability. Saccharomyces boulardii fosters epithelial cells and maintains intestinal electrolyte and enzyme balance. It helps for maintaining normal frequency of bowel movement and normal texture of intestinal contents.

Lactobacillus rhamnosus GG is among the best studied probiotic strains with clinically evidenced benefits in maintaining the physiological frequency of bowel movements. The ingredient attaches itself to the intestinal wall, produces metabolites which are favourable for the normal functioning of the intestines and increases the population of good bacteria residing in the guts. It is remarkably good for nourishing the intestinal epithelial cells and maintaining the normal barrier function of the intestinal mucosa. Furthermore, Lactobacillus rhamnosus GG interacts with the cells of the immune system located in the gastrointestinal tract, exerting a beneficial effect on local immunity and additionally contributing to maintaining the health of the gastrointestinal tract.

Mannan-oligosaccharide (MOS) are prebiotics which are sugars of a specific structure and origin (derived from yeast cell wall). The intake of MOS leads to an increase in good bacteria in the intestines and supports their effect on the local immunity in the intestinal tract. Furthermore, the specific structure of MOS prevents bad bacteria from persisting in the intestines, thus additionally facilitating the intestinal flora balance.

Zinc is a micronutrient which works on ion transport in the intestines to ensure optimal physiological water and salts levels and texture of the intestinal contents. It favours the normal barrier function of the intestinal wall.

 

WHO SHOULD NOT TAKE ADIREX BABY?

Do not take ADIREX BABY if you have ever had an allergic reaction to any of its ingredients.

 

WHAT ARE THE SIDE EFFECTS OF ADIREX BABY?

There are no known side effects of the product so far.

 

HOW TO TAKE ADIREX BABY?

It is recommended to start taking ADIREX BABY as soon as the onset of the first signs that it needs to be taken.

ADIREX BABY is intended for use by children to 3 years of age.

The recommended dose is 1 sachet 2 times daily.

Dissolve the content of the sachet in some water or soft drink, stir and drink. It can also be mixed with food.

Do not take ADIREX BABY with hot or alcoholic drinks, to avoid killing the live bacteria in the sachet.

 

STORAGE

Store ADIREX BABY in its original package at a temperature of up to 25° ะก, in a dry place, protected from direct sunlight and away from children.

Do not use the product after the expiry date or if the package has been opened or damaged.